Leptinol and process for making the same



, Patented Sept. 1, 1925.

UNITED STATES PATENT OFFICE.

ERNST THEODOR KREBS, OF SAN FRANCISCO, CALIFORNIA.

LEIPTINOL AND PROCESS FOR MAKING THE SAME.

N 0 Drawing.

To all whom it may concern:

Be it known that I, ERNST THEODOR EBS, a citizen of the United States,and a resident of San Francisco, in the county of San Francisco andState of California, have invented certain new and useful Improvementsin Leptinol and Processes for Making the Same, of which the following isa specification.

This invention relates to a medicinal preparation and a process forextracting the same from the roots of leptotaenia dissecta.

An object of the invention is the provision of a process for removingundesirable constituents of the roots of leptotaenia dissecta andmodifying the extracted oils and resins to such an extent that they willbe soluble in water and therefore more effective as a medicinalpreparation.

A further object of the invention is the provision of a medicinalpreparation made from the roots of leptotaenia dissecta by theelimination of gums and other undesirable constituents and thesaponification of the oils and resins contained in the roots therebyproviding a more soluble and more readily assimilated preparation whentaken internally.

In order to obtain the leptinol I out the oots of leptotaenia dissectainto small particles in any well known manner and place them in a dryingshed, taking care that the sun-light does not fall upon the same. The

chopped roots are laid out fiat and the shed is well ventilated topermit the air to pass freely through the same to aid in the dryin ofthe roots. The roots may be thoroughly dried in a dessicating machineand when thoroughly dried are ground to a coarse powder and thismaterial is firmly packed 1n percolators in the same manner as isemployed in the preparation of tinctures or fluid extracts. It ispermitted to macerate in alcohol of high proof for one or more days andthen allowed to percolate. The alcoholic extract thus obtained has aproximately the strength of ordinary fluid exg cipitate gums andApplication filed April 23, 1923. Serial No. 634,178.

tract, that is, one pint of the extract representing one pound of thedrug.

This alcoholic solution or extract is treated with approximately 2 percent of a saturated alcoholic solution of an alkaline hydroxidepreferably potash or soda and the mixture is agitated vigorously untilthe reaction has been completed and the gums The alcoholic solution issiphoned or filtered and it is this solution which I term leptinol andthe product is more soluble in water and is therefore more readilyassimilated by the digestive system. I

The product thus obtained and which I designate as leptinol is valuablefor its medicinal granulations when applied to wounds or sores.

What I claim is: 1. A process for making leptinol which conslsts intreating the roots of le totaenia dissecta with alcohol, removing t egum from the alcoholic extract and saponifying the resins and oils ofsaid extract.

2. A process for making leptinol which 1n treating the roots ofleptotaenia dissecta with alcohol, to form an alcoholic extract of thesame, treating such alcoholic extract with an alkaline hydroxide to preother undesirable ele ments, and simultaneously saponify oils andresins. Y

3. A process for making leptinol which consists in treating the roots ofleptotaenia dissecta with alcohol of high proof to form an alcoholicextract, treatlng such extract with a saturated alcoholic solution of anal- 90 kaline hydroxide and then vigorously agitating the mixture.

4. A process for making leptinol which consists in treating the roots ofleptotaenia a menses dissecta with alcohol to form an alcoholicalcoholic solution of an alkaline h droxide, extract, treating thealcoholic extract with shaking the same vi orously, and t en sepa- 2 percent of an alcoholic saturated solution rating the solution m theprecipitate. of an alkaline h droxide. 6. A medicinal compound comprisinan 6 5. A recess or the manufacture of lept-ialcoholic extract ofleptotaenia disseeta grom nol which consists in drying the roots ofwhich the gums and other undesirable eleleptotaenia disecta, grindmg thedried roots ments have been removed and in which the into a fine powder,causing alcohol to peroils and resins have been saponified.colatethrough the powder to form an al- 0 coholic extract,treatmg suchextract with an ERNST THEODOR KREBS.

